Limitations and pitfalls of 99mTc-EDDA/HYNIC-TOC (Tektrotyd) scintigraphy

Tektrotyd kit was developed by Polatom company for 99mTc labeling to make an alternative tracer of somatostatin receptor scintigraphy available. Since 2005, 99mTc-EDDA/HYNIC-Tyr3-Octreotide has been used in clinical imaging and achieved high impact in management of patients with neuroendocrine tumors. Knowing the limitations and pitfalls is essential to provide ac­curate diagnosis. Therefore, the potential pitfalls associated with the use of 99mTc-EDDA/HYNIC-TOC are reviewed on the basis of own experience. Data were analyzed of 310 patients who underwent somatostatin receptor scintigraphy with 99mTc-Tektrotyd. Pitfalls during radiolabeling process or acquisition can worsen the sensitivity of SRS (somatostatin receptor scintigraphy). Recognizing physi­ological and clinical pitfalls, the diagnostic accuracy will improve

Hibrid képalkotás: klinikai evidenciák, lehetőségek

Absztrakt Napjainkban a radiológia és nukleáris medicina modern képalkotó berendezéseit ötvöző hibrid képalkotás fontos szerepet tölt be mind a transzlációs kutatási folyamatokban, mind pedig a klinikai diagnosztikában. A rutin képalkotó diagnosztikai eljárások közül a komputertomográffal vagy mágneses magrezonanciás képalkotással kombinált pozitronemissziós tomográfia, illetve egyfotonos emissziós komputertomográfiás vizsgálat jelenleg a legfejlettebb technikák közé tartozik, amelynek segítségével a funkcionális és a morfológiai képeket azonos pozícióban tudjuk egymásra vetíteni. A hibrid képalkotó berendezések a nagy érzékenységüknek, jó felbontásuknak köszönhetően hasznos információt nyújtanak a szervezetben zajló patológiás folyamatokról. Segítségükkel megismerhetők olyan biokémiai és patobiokémiai folyamatok, amelyek elengedhetetlenek a betegségek megértéséhez, kezeléséhez vagy egy új, gyógyszerjelölt molekula megismeréséhez. A klinikai és preklinikai in vivo nem invazív molekuláris képalkotó rendszerek segítségével a gyógyszerfejlesztés folyamata lerövidíthető, költségei csökkenthetők. Orv. Hetil., 2015, 156(52), 2110–2115

The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves’ orbitopathy

The pathogenesis of Graves’ orbitopathy (GO) is not completely understood. Coexistent hyperfunction of the thyroid gland is frequent; however, GO may also coexist with hypo- or euthyrodism. The course of GO is largely independent of thyroid function, although elevated serum TSH is known to negatively interfere with GO course. GO is severe in 10% of the cases; sight threatening complications may also develop. A successful therapy of GO requires the assesment of both the severity and activity of orbital inflammation. Based on relevant studies and our own experiences, the possible management choices are reviewed here. For this purpose, we compare the clinical value of imaging techniques for detecting the activity of the disease. During the last 15 years, we used 99mTc-DTPA retrobulbar SPECT routinely in more than 1400 patients to facilitate the right therapeutic decision. This diagnostic utility simplified management decisions compared to previously applied alternative techniques. We recommended the routine use of 99mTc-DTPA retrobulbar SPECT for the evaluation and follow-up of GO.The pathogenesis of Graves’ orbitopathy (GO) is not completely understood. Coexistent hyperfunction of the thyroid gland is frequent; however, GO may also coexist with hypo- or euthyrodism. The course of GO is largely independent of thyroid func­tion, although elevated serum TSH is known to negatively interfere with GO course. GO is severe in 10% of the cases; sight threatening complications may also develop. A successful therapy of GO requires the assesment of both the severity and activity of orbital inflammation. Based on relevant studies and our own experiences, the possible management choices are reviewed here. For this purpose, we compare the clinical value of imaging techniques for detecting the activity of the disease. During the last 15 years, we used 99mTc-DTPA retrobulbar SPECT routinely in more than 1400 patients to facilitate the right therapeutic decision. This diagnostic utility simplified management decisions compared to previously applied alternative techniques. We recommended the routine use of 99mTc-DTPA retrobulbar SPECT for the evaluation and follow-up of GO.

Clinical utility of SPECT/CT and CT-dacryocystography-enhanced dacryoscintigraphy in the imaging of lacrimal drainage system obstruction

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Kutatási füzetek 08. : Négy tanulmány

Szerkesztők: Garai Ildikó; Vitári Zsolt | További szerzők: Vitári Zsolt; Bátori Zsolt; Kánya József; Nagy Edit | Cím: Kutatási füzetek 8. | Alcím: Négy tanulmány : Történelem doktori program | Megjelenési adatok: Janus Pannonius Tudományegyetem, Pécs, 2001. | Megjegyzés: A Kutatási Füzetek a Janus Pannonius Tudományegyetem Európa és Magyarország a 19-20. században című történelem doktori (Ph.D.) programjának sorozata.(1) Bátori Zsolt: A tömegek helye Lenin politikai gondolkodásában 7-42 | (2) Kánya József: A székely körvasút regionális hatásai 43-53 | (3) Nagy Edit: A szocialista gazdaság alkalmazkodási kísérletei Magyarországon a hetvenes években 54-76 | (4) Vitári Zsolt: A testi felkészítés előzményei a Hitlerjugendben 1933 előtt 77-9

Body fat distribution and metabolic consequences — Examination opportunities in dogs

The relationship between metabolic disorders and the distribution of fat in different body regions is not clearly understood in humans. The aim of this study was to develop a suitable method for assessing the regional distribution of fat deposits and their metabolic effects in dogs. Twenty-five dogs were subjected to computed tomographic (CT) imaging and blood sampling in order to characterise their metabolic status. The different fat areas were measured on a cross-sectional scan, and the animals’ metabolic status was evaluated by measuring fasting glucose, insulin and leptin levels. The volume of visceral adipose tissue is the main determinant of leptin levels. The correlation of visceral fat volume and leptin concentration was found to be independent of insulin levels or the degree of insulin resistance. There was a positive correlation between the visceral to subcutaneous fat volume ratio and serum insulin concentration, and a similar trend was observed in the relationship of fat ratio and insulin resistance. The distribution of body fat essentially influences the metabolic parameters in dogs, but the effects of adiposity differ between humans and dogs. The findings can facilitate a possible extrapolation of results from animal studies to humans with regard to the metabolic consequences of different obesity types